'Artificial bone' customized for my body gives an answer.
Development of 'Bone Defect and Disease Fusion Therapy’
Mr. I-am-not-a-loser, who has been living timidly because of his short height.
Mr. Accident-again, who had a bone fracture because of an unexpected accident.
Ms. I-am-alienated, who has been suffering from deformed limbs.
The reason that they could go back to their community with a smile was because of the help of high-tech modern medicine, such as Ilizarov technique.
Ilizarov technique is being widely used for the treatment of loss and disease related with bone as well as rare musculoskeletal refractory diseases, with the principle which allows the generation of a new bone in 1 mm of space made by cutting the normal bone near the affected bone and firmly fixating with an external fixator on a daily basis.
However, it requires constant endurance since it takes 30 days for 1cm of normal growth,
and there are problems, such as the reoperation due to a failure of fixation of artificial bone being implanted for the promotion of osteogenesis, and the administration of additional antibiotics due to a bacterial infection.
Hereupon, Korea University Medical Center is trying to apply 'Bone Fracture Package,' a combination of muscle, skin, artificial bone, external fixator and bone growth factor for the full recovery of bone defect and disease, to the clinical field.
Especially, the medical center is accelerating the research and development of a technique to manufacture the artificial bone, which is the core of the treatment.
'Antibiotics and osteoinductive molecules-eluting implant or scaffold with enhanced osteointegration and antibacterial activity and the manufacturing method thereof,' an artificial bone manufacturing technique name by Korea University Medical Center,
is trying to shorten the treatment time by decreasing the implantation failure rate due to the bacteria and promoting the osteogenesis.
Polymethylmethacrylate (PMMA) has a difficulty in the control of releasing antibiotics and a disadvantage of secondary operation for removal,
allogenous bone grafting with a bone from dead person, etc. requires reoperation because of low osteogenesis,
autogenous bone grafting has a risk of complications such as pain and infection after the surgery because the bone tissue is obtained from the patient's own body part.
Artificial bone manufacturing technique of Korea University Medical Center supplemented a disadvantage of artificial bone
by fixating antibiotics and BMP-2, a growth factor promoting osteogenesis, sequentially on the titanium surface treated with dopamine and heparin.
Therefore, implantation failure rate is remarkably decreased by preventing a bacterial infection during or after the implantation due to the long-term continuous release of antibiotics.
Also, the treatment period can be shortened by up to 10 days since osteogenesis is increased by the promotion of adherence between artificial bone and bone tissue and the differentiation of osteoblast due to the long-term continuous release of BMP-2 which promotes bone fusion and osteogenesis.
Above all things, financial burden due to the reoperation can be reduced because the implantation success rate is high since an artificial bone personalized for the affected area of each patient can be manufactured.
3D bio printing technology, stem cell and artificial bone surface coating technology for the mass production of artificial bone manufacture are also being developed.
BMP-2(Growth factor) market led by the U.S. is worth KRW 1 trillion creating a massive economic value just in the U.S.,
and the artificial bone market will be grown into larger scale since patients with bone defect and disease are increasing due to the aging of population.
In this situation, an excellent technique of 'Bone Fracture Package,' a bone defect and disease fusion therapy of Korea University Medical Center, will take a leading role in the medical market in Korea as well as the development of a blue ocean.
'Artificial bone' customized for my body gives an answer.
Development of 'Bone Defect and Disease Fusion Therapy’
Mr. I-am-not-a-loser, who has been living timidly because of his short height.
Mr. Accident-again, who had a bone fracture because of an unexpected accident.
Ms. I-am-alienated, who has been suffering from deformed limbs.
The reason that they could go back to their community with a smile was because of the help of high-tech modern medicine, such as Ilizarov technique.
Ilizarov technique is being widely used for the treatment of loss and disease related with bone as well as rare musculoskeletal refractory diseases, with the principle which allows the generation of a new bone in 1 mm of space made by cutting the normal bone near the affected bone and firmly fixating with an external fixator on a daily basis.
However, it requires constant endurance since it takes 30 days for 1cm of normal growth,
and there are problems, such as the reoperation due to a failure of fixation of artificial bone being implanted for the promotion of osteogenesis, and the administration of additional antibiotics due to a bacterial infection.
Hereupon, Korea University Medical Center is trying to apply 'Bone Fracture Package,' a combination of muscle, skin, artificial bone, external fixator and bone growth factor for the full recovery of bone defect and disease, to the clinical field.
Especially, the medical center is accelerating the research and development of a technique to manufacture the artificial bone, which is the core of the treatment.
'Antibiotics and osteoinductive molecules-eluting implant or scaffold with enhanced osteointegration and antibacterial activity and the manufacturing method thereof,' an artificial bone manufacturing technique name by Korea University Medical Center,
is trying to shorten the treatment time by decreasing the implantation failure rate due to the bacteria and promoting the osteogenesis.
Polymethylmethacrylate (PMMA) has a difficulty in the control of releasing antibiotics and a disadvantage of secondary operation for removal,
allogenous bone grafting with a bone from dead person, etc. requires reoperation because of low osteogenesis,
autogenous bone grafting has a risk of complications such as pain and infection after the surgery because the bone tissue is obtained from the patient's own body part.
Artificial bone manufacturing technique of Korea University Medical Center supplemented a disadvantage of artificial bone
by fixating antibiotics and BMP-2, a growth factor promoting osteogenesis, sequentially on the titanium surface treated with dopamine and heparin.
Therefore, implantation failure rate is remarkably decreased by preventing a bacterial infection during or after the implantation due to the long-term continuous release of antibiotics.
Also, the treatment period can be shortened by up to 10 days since osteogenesis is increased by the promotion of adherence between artificial bone and bone tissue and the differentiation of osteoblast due to the long-term continuous release of BMP-2 which promotes bone fusion and osteogenesis.
Above all things, financial burden due to the reoperation can be reduced because the implantation success rate is high since an artificial bone personalized for the affected area of each patient can be manufactured.
3D bio printing technology, stem cell and artificial bone surface coating technology for the mass production of artificial bone manufacture are also being developed.
BMP-2(Growth factor) market led by the U.S. is worth KRW 1 trillion creating a massive economic value just in the U.S.,
and the artificial bone market will be grown into larger scale since patients with bone defect and disease are increasing due to the aging of population.
In this situation, an excellent technique of 'Bone Fracture Package,' a bone defect and disease fusion therapy of Korea University Medical Center, will take a leading role in the medical market in Korea as well as the development of a blue ocean.